Journal article
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
SEH Solvang, A Hodge, LO Watne, O Cabral-Marques, JE Nordrehaug, GG Giles, PA Dugué, O Nygård, PM Ueland, A Mccann, AV Idland, Ø Midttun, A Ulvik, NB Halaas, GS Tell, LM Giil
Oxidative Medicine and Cellular Longevity | Published : 2022
DOI: 10.1155/2022/5019752
Abstract
The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine metabolites and their associations with age and change over time in four cohorts using comprehensive, targeted metabolomics. The study included 1574 participants in two cohorts with repeated metabolite measurements (mean age at baseline 58 years±8 SD and 62±10 SD), 3161 community-dwelling older adults (age range 71-74 years), and 109 CSF donors (mean age 73 years±7 SD). In the first two cohorts, age was associated with kynurenine (Kyn), quinolinic acid (QA), and the kyn..
View full abstractRelated Projects (3)
Grants
Awarded by Norwegian Health Association, Dementia Research Program
Awarded by Australian National Health and Medical Research Council
Funding Acknowledgements
We would like to thank all the study participants, researchers, and staff in the COGNORM- study, the Melbourne Collaborative Cohort Study, the Hordaland Health Study, and the Western Norway B Vitamin Intervention Trial. The study was funded by the Norwegian Health Association, Dementia Research Program (contract number: 7349). The MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council grants 209057, 396414, 1074383, and 1106016 by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database. The COGNORM study is funded by the Norwegian Health Association, the Medical Student Research Program at the University of Oslo, and the South-Eastern Norway Regional Health Authorities. A manuscript of this article was published in the doctoral thesis: The Kynurenine pathway in cognition, dementia, and aging [63].